Differential Targeting of Gβγ-Subunit Signaling with Small Molecules
Differential Targeting of Gβγ-Subunit Signaling with Small Molecules
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Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
G protein βγ subunits have potential as a target for therapeutic treatment of a number of diseases. We performed virtual docking of a small-molecule library to a site on Gβγ subunits that mediates protein interactions. We hypothesized that differential targeting of this surface could allow for selective modulation of Gβγ subunit functions. Several...
Alternative Titles
Full title
Differential Targeting of Gβγ-Subunit Signaling with Small Molecules
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Record Identifier
TN_cdi_pascalfrancis_primary_17752225
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pascalfrancis_primary_17752225
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1120378
