Direct Characterization of Factor VIII in Plasma: Detection of a Mutation Altering a Thrombin Cleava...
Direct Characterization of Factor VIII in Plasma: Detection of a Mutation Altering a Thrombin Cleavage Site (arginine-372 → histidine)
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Publisher
Washington, DC: National Academy of Sciences of the United States of America
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Language
English
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Washington, DC: National Academy of Sciences of the United States of America
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Contents
An immunoadsorbent method has been developed for the direct analysis of normal and variant plasma factor VIII. Using this method, the molecular defect responsible for mild hemophilia A has been identified for a patient whose plasma factor VIII activity is 0.05 unit/ml, even though the factor VIII antigen content is 3.25 units/ml. Although the varia...
Alternative Titles
Full title
Direct Characterization of Factor VIII in Plasma: Detection of a Mutation Altering a Thrombin Cleavage Site (arginine-372 → histidine)
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Record Identifier
TN_cdi_pascalfrancis_primary_19610690
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pascalfrancis_primary_19610690
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.86.11.4277
