Glucocorticoids Selectively Inhibit the Transcription of the Interleukin 1β Gene and Decrease the St...
Glucocorticoids Selectively Inhibit the Transcription of the Interleukin 1β Gene and Decrease the Stability of Interleukin 1β mRNA
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Publisher
Washington, DC: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
Washington, DC: National Academy of Sciences of the United States of America
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Contents
Transcription of the interleukin 1β (IL-1β ) gene was studied by mRNA hybridization with a cDNA probe in the human promonocytic cell line U-937. Phorbol ester and lipopolysaccharide increased the steady-state level of IL-1β mRNA. Glucocorticoids markedly decreased IL-1β mRNA levels by two mechanisms. Transcription of the IL-1 gene was inhibited, as...
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Full title
Glucocorticoids Selectively Inhibit the Transcription of the Interleukin 1β Gene and Decrease the Stability of Interleukin 1β mRNA
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Record Identifier
TN_cdi_pascalfrancis_primary_7609615
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pascalfrancis_primary_7609615
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.85.4.1204
