Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo spl...
Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania donovani to screen chemical compounds for anti-leishmanial activit...
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Full title
Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system
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TN_cdi_plos_journals_1288108120
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1288108120
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ISSN
1935-2735,1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0000962
