Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disru...
Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disrupts Egg Production in Schistosoma mansoni
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
P-glycoprotein (Pgp) and multidrug resistance-associated proteins (MRPs) are ATP-dependent transporters involved in efflux of toxins and xenobiotics from cells. When overexpressed, these transporters can mediate multidrug resistance (MDR) in mammalian cells, and changes in Pgp expression and sequence are associated with drug resistance in helminths...
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Full title
Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disrupts Egg Production in Schistosoma mansoni
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TN_cdi_plos_journals_1288114079
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1288114079
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ISSN
1935-2735,1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0001425
