Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions
Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Quinacrine is a potent antiprion compound in cell culture models of prion disease but has failed to show efficacy in animal bioassays and human clinical trials. Previous studies demonstrated that quinacrine inefficiently penetrates the blood-brain barrier (BBB), which could contribute to its lack of efficacy in vivo. As quinacrine is known to be a...
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Full title
Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions
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TN_cdi_plos_journals_1289058663
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289058663
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1000673
