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Phase variable O antigen biosynthetic genes control expression of the major protective antigen and b...

Phase variable O antigen biosynthetic genes control expression of the major protective antigen and b...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289096999

Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1

About this item

Full title

Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2012-09, Vol.8 (9), p.e1002917-e1002917

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The Vibrio cholerae lipopolysaccharide O1 antigen is a major target of bacteriophages and the human immune system and is of critical importance for vaccine design. We used an O1-specific lytic bacteriophage as a tool to probe the capacity of V. cholerae to alter its O1 antigen and identified a novel mechanism by which this organism can modulate O a...

Alternative Titles

Full title

Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1289096999

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289096999

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1002917

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