CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
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Author / Creator
Peretz, Yoav , He, Zhong , Shi, Yu , Yassine-Diab, Bader , Goulet, Jean-Philippe , Bordi, Rebeka , Filali-Mouhim, Ali , Loubert, Jean-Baptiste , El-Far, Mohamed , Dupuy, Franck P. , Boulassel, Mohamed Rachid , Tremblay, Cécile , Routy, Jean-Pierre , Bernard, Nicole , Balderas, Robert , Haddad, Elias K. and Sékaly, Rafick-Pierre
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Chronic viral infections lead to persistent CD8 T cell activation and functional exhaustion. Expression of programmed cell death-1 (PD-1) has been associated to CD8 T cell dysfunction in HIV infection. Herein we report that another negative regulator of T cell activation, CD160, was also upregulated on HIV-specific CD8 T lymphocytes mostly during t...
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Full title
CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
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TN_cdi_plos_journals_1289105775
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289105775
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1002840
