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Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289111252

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

About this item

Full title

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2012-12, Vol.8 (12), p.e1003087

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The striking differences between the clinical symptoms of tetanus and botulism have been ascribed to the different fate of the parental neurotoxins once internalised in motor neurons. Tetanus toxin (TeNT) is known to undergo transcytosis into inhibitory interneurons and block the release of inhibitory neurotransmitters in the spinal cord, causing a...

Alternative Titles

Full title

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1289111252

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289111252

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1003087

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