Aging and replicative senescence have related effects on human stem and progenitor cells
Aging and replicative senescence have related effects on human stem and progenitor cells
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Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
The regenerative potential diminishes with age and this has been ascribed to functional impairments of adult stem cells. Cells in culture undergo senescence after a certain number of cell divisions whereby the cells enlarge and finally stop proliferation. This observation of replicative senescence has been extrapolated to somatic stem cells in vivo...
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Full title
Aging and replicative senescence have related effects on human stem and progenitor cells
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TN_cdi_plos_journals_1289198419
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289198419
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0005846
