Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin condi...
Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Presenilins are the major causative genes of familial Alzheimer's disease (AD). Our previous study has demonstrated essential roles of presenilins in memory and neuronal survival. Here, we explore further how loss of presenilins results in age-related, progressive neurodegeneration in the adult cerebral cortex, where the pathogenesis of AD occurs....
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Full title
Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice
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TN_cdi_plos_journals_1289443569
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289443569
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0010195
