Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Pro...
Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved.
We co-embedded single cancer cells with fluorescent micro-beads in agarose gels and, using...
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Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells
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TN_cdi_plos_journals_1289961522
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289961522
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0004632
