Impaired Replication Stress Response in Cells from Immunodeficiency Patients Carrying Cernunnos/XLF...
Impaired Replication Stress Response in Cells from Immunodeficiency Patients Carrying Cernunnos/XLF Mutations
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Non-Homologous End Joining (NHEJ) is one of the two major pathways of DNA Double Strand Breaks (DSBs) repair. Mutations in human NHEJ genes can lead to immunodeficiency due to its role in V(D)J recombination in the immune system. In addition, most patients carrying mutations in NHEJ genes display developmental anomalies which are likely the result...
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Full title
Impaired Replication Stress Response in Cells from Immunodeficiency Patients Carrying Cernunnos/XLF Mutations
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TN_cdi_plos_journals_1289963993
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1289963993
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0004516
