A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of bet...
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is responsible for several phosphorylation events that mark beta-catenin for ubiquitination and subsequent...
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Full title
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling
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TN_cdi_plos_journals_1291078917
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1291078917
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0006892
