Hepatitis C Virus Controls Interferon Production through PKR Activation
Hepatitis C Virus Controls Interferon Production through PKR Activation
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. Low IFN induction has been attributed to HCV NS3/4A protease-mediated cleavage of the mitochondria-adapter MAVS. Here, we have investigated the early events of IFN induction upon HCV inf...
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Full title
Hepatitis C Virus Controls Interferon Production through PKR Activation
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TN_cdi_plos_journals_1291893746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1291893746
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0010575
