Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic [beta] Cells: e31
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic [beta] Cells: e31
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Publisher
San Francisco: Public Library of Science
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Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secretion in pancreatic β cells. Sirt1 represses the unc...
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Full title
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic [beta] Cells: e31
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TN_cdi_plos_journals_1291896888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1291896888
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ISSN
1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.0040031
