Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
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United States: Public Library of Science
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English
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United States: Public Library of Science
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7,8-dihydro-8-oxoguanine (oxoG), the predominant lesion formed following oxidative damage of DNA by reactive oxygen species, is processed differently by replicative and bypass polymerases. Our kinetic primer extension studies demonstrate that the bypass polymerase Dpo4 preferentially inserts C opposite oxoG, and also preferentially extends from the...
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Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
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TN_cdi_plos_journals_1291896949
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1291896949
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.0040011
