Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophag...
Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia (B-CLL) was investigated in different CML cell...
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Full title
Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death
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TN_cdi_plos_journals_1292119849
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292119849
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0007889
