Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection...
Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
HIV's ability to establish long-lived latent infection is mainly due to transcriptional silencing in resting memory T lymphocytes and other non dividing cells including monocytes. Despite an undetectable viral load in patients treated with potent antiretrovirals, current therapy is unable to purge the virus from these latent reservoirs. In order to...
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Full title
Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner
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TN_cdi_plos_journals_1292136618
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292136618
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0011160
