Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human No...
Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our previous work showed the importance of activated AKT in mediating resistance of non-small cell lung cancer (NSCLC) to AZD6244. Thus we hypothesized that dual inhibition of both downstream MEK an...
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Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo
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TN_cdi_plos_journals_1292207482
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292207482
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0014124
