Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy
Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy
About this item
Full title
Author / Creator
Publisher
San Francisco: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
San Francisco: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Background The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1). Methodology/Principal Findings We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1α. Cardiac function steadily decreased with transgene expr...
Alternative Titles
Full title
Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1292305722
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292305722
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0011693
