Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, is responsible for spinocerebellar ataxia type 1. Requirements for developing the disease are polyQ expansion, nuclear localization and phosphorylation of S776. Using a combination of bioinformatics, cell and structural biology approaches, we have identified a UHM ligan...
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Full title
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors
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TN_cdi_plos_journals_1292310239
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292310239
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0008372
