Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon...
Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The KRAS proto-oncogene plays a key role in the development of many human tumors and is commonly activated by somatic mutation or signaling through specific growth factor receptors. However, the interaction between the micro-environment and K-ras activity has not been defined. Hypoxia invariably develops as tumors outgrow their supply of oxygen. A...
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Full title
Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells
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TN_cdi_plos_journals_1292429065
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292429065
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0010966
