Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dyn...
Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics
About this item
Full title
Author / Creator
Rolland, Morgane , Carlson, Jonathan M. , Manocheewa, Siriphan , Swain, J. Victor , Lanxon-Cookson, Erinn , Deng, Wenjie , Rousseau, Christine M. , Raugi, Dana N. , Learn, Gerald H. , Maust, Brandon S. , Coovadia, Hoosen , Ndung'u, Thumbi , Goulder, Philip J. R. , Walker, Bruce D. , Brander, Christian , Heckerman, David E. and Mullins, James I.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolutionary pathways, we investigated AA co-variation in Gag sequen...
Alternative Titles
Full title
Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics
Authors, Artists and Contributors
Author / Creator
Carlson, Jonathan M.
Manocheewa, Siriphan
Swain, J. Victor
Lanxon-Cookson, Erinn
Deng, Wenjie
Rousseau, Christine M.
Raugi, Dana N.
Learn, Gerald H.
Maust, Brandon S.
Coovadia, Hoosen
Ndung'u, Thumbi
Goulder, Philip J. R.
Walker, Bruce D.
Brander, Christian
Heckerman, David E.
Mullins, James I.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1292546085
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292546085
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0012463
