Downregulation of Homologous Recombination DNA Repair Genes by HDAC Inhibition in Prostate Cancer Is...
Downregulation of Homologous Recombination DNA Repair Genes by HDAC Inhibition in Prostate Cancer Is Mediated through the E2F1 Transcription Factor
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Author / Creator
Kachhap, Sushant K. , Rosmus, Nadine , Collis, Spencer J. , Kortenhorst, Madeleine S. Q. , Wissing, Michel D. , Hedayati, Mohammad , Shabbeer, Shabana , Mendonca, Janet , Deangelis, Justin , Marchionni, Luigi , Lin, Jianqing , Höti, Naseruddin , Nortier, Johan W. R. , DeWeese, Theodore L. , Hammers, Hans and Carducci, Michael A.
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Histone deacetylase inhibitors (HDACis) re-express silenced tumor suppressor genes and are currently undergoing clinical trials. Although HDACis have been known to induce gene expression, an equal number of genes are downregulated upon HDAC inhibition. The mechanism behind this downregulation remains unclear. Here we provide evidence that several D...
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Full title
Downregulation of Homologous Recombination DNA Repair Genes by HDAC Inhibition in Prostate Cancer Is Mediated through the E2F1 Transcription Factor
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TN_cdi_plos_journals_1292617210
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292617210
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0011208
