The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar f...
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the extent and timing of GNP proliferation, as well as GNP...
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Full title
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation
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TN_cdi_plos_journals_1292617331
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292617331
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0017884
