Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats
Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats
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United States: Public Library of Science
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English
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United States: Public Library of Science
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In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene.
We analysed the structure of polymerase chain reaction (PCR)-generated DNA containing up to 585 CAG repeats using atomic force mic...
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Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats
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TN_cdi_plos_journals_1292661805
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292661805
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0017119
