ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.
Here, we show that the rho guanine nucleotide exchange factor ARHGEF7 and the small GTPase CDC42 are interacting with LRRK2 in vitr...
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Full title
ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
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TN_cdi_plos_journals_1292830576
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292830576
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0013762
