Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene
Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Although reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Currently, some 46 non-synonymous VUS entries exist i...
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Full title
Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene
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TN_cdi_plos_journals_1292885263
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1292885263
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0018380
