Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol
Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by blocking viral fusion with host cell membrane. To better understand Arb mechanism of action, we investigated its interactions with phospholipids and membrane peptides. We demonstrate that Arb associates with phospholipids in the micromolar range. NMR reveals that...
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Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol
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TN_cdi_plos_journals_1293453629
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1293453629
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0015874
