Isolation of Proteinase K-Sensitive Prions Using Pronase E and Phosphotungstic Acid
Isolation of Proteinase K-Sensitive Prions Using Pronase E and Phosphotungstic Acid
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Disease-related prion protein, PrP(Sc), is classically distinguished from its normal cellular precursor, PrP(C), by its detergent insolubility and partial resistance to proteolysis. Molecular diagnosis of prion disease typically relies upon detection of protease-resistant fragments of PrP(Sc) using proteinase K, however it is now apparent that the...
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Full title
Isolation of Proteinase K-Sensitive Prions Using Pronase E and Phosphotungstic Acid
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TN_cdi_plos_journals_1296286364
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1296286364
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0015679
