Epigenetic-genetic chromosome dosage approach for fetal trisomy 21 detection using an autosomal gene...
Epigenetic-genetic chromosome dosage approach for fetal trisomy 21 detection using an autosomal genetic reference marker
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The putative promoter of the holocarboxylase synthetase (HLCS) gene on chromosome 21 is hypermethylated in placental tissues and could be detected as a fetal-specific DNA marker in maternal plasma. Detection of fetal trisomy 21 (T21) has been demonstrated by an epigenetic-genetic chromosome dosage approach where the amount of hypermethylated HLCS i...
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Full title
Epigenetic-genetic chromosome dosage approach for fetal trisomy 21 detection using an autosomal genetic reference marker
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TN_cdi_plos_journals_1296287778
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1296287778
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0015244
