GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β...
GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Thyrotropin-releasing hormone (TRH) activates not only the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes. TSHβ expression is maintained by two transcription factors, Pit1 and GATA2, and is negatively regulated by thyroid hormone (T3). Our prior studies suggest that the main activator of th...
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Full title
GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene
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TN_cdi_plos_journals_1296301598
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1296301598
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0018667
