The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th...
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immunological consequences of the protective IL23R R381Q gene...
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Full title
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
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TN_cdi_plos_journals_1296322532
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1296322532
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0017160
