Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leuke...
Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia
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Author / Creator
Vilas–Zornoza, Amaia , Agirre, Xabier , Martín-Palanco, Vanesa , Martín-Subero, José Ignacio , San José-Eneriz, Edurne , Garate, Leire , Álvarez, Sara , Miranda, Estíbaliz , Rodríguez-Otero, Paula , Rifón, José , Torres, Antonio , Calasanz, María José , Cigudosa, Juan Cruz , Román-Gómez, José and Prósper, Felipe
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methylated in more than 10% of ALL samples. Interesting...
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Full title
Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia
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TN_cdi_plos_journals_1296440158
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1296440158
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0017012
