Evolutionary Analyses of Entire Genomes Do Not Support the Association of mtDNA Mutations with Ras/M...
Evolutionary Analyses of Entire Genomes Do Not Support the Association of mtDNA Mutations with Ras/MAPK Pathway Syndromes
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Gómez-Carballa, Alberto , Cerezo, María , Balboa, Emilia , Heredia, Claudia , Castro-Feijóo, Lidia , Rica, Itxaso , Barreiro, Jesús , Eirís, Jesús , Cabanas, Paloma , Martínez-Soto, Isabel , Fernández-Toral, Joaquín , Castro-Gago, Manuel , Pombo, Manuel , Carracedo, Ángel , Barros, Francisco and Salas, Antonio
Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
There are several known autosomal genes responsible for Ras/MAPK pathway syndromes, including Noonan syndrome (NS) and related disorders (such as LEOPARD, neurofibromatosis type 1), although mutations of these genes do not explain all cases. Due to the important role played by the mitochondrion in the energetic metabolism of cardiac muscle, it was...
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Full title
Evolutionary Analyses of Entire Genomes Do Not Support the Association of mtDNA Mutations with Ras/MAPK Pathway Syndromes
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TN_cdi_plos_journals_1297337837
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1297337837
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0018348
