Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with...
Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP
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Author / Creator
Palendira, Umaimainthan , Low, Carol , Chan, Anna , Hislop, Andrew D. , Ho, Edwin , Phan, Tri Giang , Deenick, Elissa , Cook, Matthew C. , Riminton, D. Sean , Choo, Sharon , Loh, Richard , Alvaro, Frank , Booth, Claire , Gaspar, H. Bobby , Moretta, Alessandro , Khanna, Rajiv , Rickinson, Alan B. and Tangye, Stuart G.
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropic virus, but not other viruses. Although previous...
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Full title
Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP
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TN_cdi_plos_journals_1299057629
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1299057629
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1001187
