The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Ess...
The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), which is uniquely permissive for V-DJβ recombination; only cells expressing pre-TCR survive and develop...
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Full title
The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement
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TN_cdi_plos_journals_1304684415
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304684415
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0020639
