Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic L...
Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease
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Author / Creator
Takeuchi, Hideyuki , Mizoguchi, Hiroyuki , Doi, Yukiko , Jin, Shijie , Noda, Mariko , Liang, Jianfeng , Li, Hua , Zhou, Yan , Mori, Rarami , Yasuoka, Satoko , Li, Endong , Parajuli, Bijay , Kawanokuchi, Jun , Sonobe, Yoshifumi , Sato, Jun , Yamanaka, Koji , Sobue, Gen , Mizuno, Tetsuya and Suzumura, Akio
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease. Although both blockade of glutamate receptors and inhibition of microglial activation are the therapeutic candida...
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Full title
Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease
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TN_cdi_plos_journals_1304812738
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304812738
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0021108
