The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and...
The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner
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Author / Creator
Kisby, Glen E. , Fry, Rebecca C. , Lasarev, Michael R. , Bammler, Theodor K. , Beyer, Richard P. , Churchwell, Mona , Doerge, Daniel R. , Meira, Lisiane B. , Palmer, Valerie S. , Ramos-Crawford, Ana-Luiza , Ren, Xuefeng , Sullivan, Robert C. , Kavanagh, Terrance J. , Samson, Leona D. , Zarbl, Helmut and Spencer, Peter S.
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a single systemic dose of MAM acetate display DNA damage...
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Full title
The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner
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TN_cdi_plos_journals_1304858960
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1304858960
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0020911
