Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by intraneuronal deposition of the nuclear TAR DNA-binding protein 43 (TDP-43) caused by unknown mechanisms. Here, we studied TDP-43 in primary neurons under different stress conditions and found that only proteasome inhibition by MG-132 or lactacysti...
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Full title
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
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TN_cdi_plos_journals_1305757691
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1305757691
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0022850
