Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
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Author / Creator
Devine, Michael J. , Kaganovich, Alice , Ryten, Mina , Mamais, Adamantios , Trabzuni, Daniah , Manzoni, Claudia , McGoldrick, Philip , Chan, Diane , Dillman, Allissa , Zerle, Julia , Horan, Susannah , Taanman, Jan-Willem , Hardy, John , Marti-Masso, Jose-Felix , Healey, Daniel , Schapira, Anthony H. , Wolozin, Benjamin , Bandopadhyay, Rina , Cookson, Mark R. , van der Brug, Marcel P. and Lewis, Patrick A.
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Point mutations in LRRK2 cause autosomal dominant Parkinson's disease. Despite extensive efforts to determine the mechanism of cell death in patients with LRRK2 mutations, the aetiology of LRRK2 PD is not well understood. To examine possible alterations in gene expression linked to the presence of LRRK2 mutations, we carried out a case versus contr...
Alternative Titles
Full title
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue
Authors, Artists and Contributors
Author / Creator
Kaganovich, Alice
Ryten, Mina
Mamais, Adamantios
Trabzuni, Daniah
Manzoni, Claudia
McGoldrick, Philip
Chan, Diane
Dillman, Allissa
Zerle, Julia
Horan, Susannah
Taanman, Jan-Willem
Hardy, John
Marti-Masso, Jose-Felix
Healey, Daniel
Schapira, Anthony H.
Wolozin, Benjamin
Bandopadhyay, Rina
Cookson, Mark R.
van der Brug, Marcel P.
Lewis, Patrick A.
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1306136420
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1306136420
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0022489
