A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia p...
A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Structural and biochemical studies of mammalian membrane proteins remain hampered by inefficient production of pure protein. We explored codon optimization based on highly expressed Pichia pastoris genes to enhance co-translational folding and production of P-glycoprotein (Pgp), an ATP-dependent drug efflux pump involved in multidrug resistance of...
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Full title
A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris
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TN_cdi_plos_journals_1306886627
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1306886627
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0022577
