Molecular Basis for the Recognition of Adenomatous Polyposis Coli by the Discs Large 1 Protein
Molecular Basis for the Recognition of Adenomatous Polyposis Coli by the Discs Large 1 Protein
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Author / Creator
Zhang, Zhenyi , Li, Hua , Chen, Leyi , Lu, Xingyu , Zhang, Jian , Xu, Ping , Lin, Kui and Wu, Geng
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The human Discs Large 1 (DLG1) protein uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein. The DLG1/APC complex inhibits the cell cycle progression from the G0/G1 to the S phase, regulates epithelial cell migration and morphogenesis, and is required for polariza...
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Full title
Molecular Basis for the Recognition of Adenomatous Polyposis Coli by the Discs Large 1 Protein
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TN_cdi_plos_journals_1308333864
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1308333864
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0023507
