Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induce...
Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease
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United States: Public Library of Science
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English
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United States: Public Library of Science
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L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission. However, so far the results of clinical and preclinical studies on the effects of opioids agonists and antagonists have been contradictory at best. Prodynorphin mRNA levels correl...
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Full title
Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease
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TN_cdi_plos_journals_1308858760
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1308858760
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0025653
