Genetic Ablation of PLA2G6 in Mice Leads to Cerebellar Atrophy Characterized by Purkinje Cell Loss a...
Genetic Ablation of PLA2G6 in Mice Leads to Cerebellar Atrophy Characterized by Purkinje Cell Loss and Glial Cell Activation
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Infantile neuroaxonal dystrophy (INAD) is a progressive, autosomal recessive neurodegenerative disease characterized by axonal dystrophy, abnormal iron deposition and cerebellar atrophy. This disease was recently mapped to PLA2G6, which encodes group VI Ca(2+)-independent phospholipase A(2) (iPLA(2) or iPLA(2)β). Here we show that genetic ablation...
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Full title
Genetic Ablation of PLA2G6 in Mice Leads to Cerebellar Atrophy Characterized by Purkinje Cell Loss and Glial Cell Activation
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TN_cdi_plos_journals_1309452251
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1309452251
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0026991
