Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several pr...
Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia. However, little is known about the molecular mechanisms that govern the level and secretion of progranulin. Here we show that progranulin is expressed in mouse cortical neurons and more prominen...
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Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins
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TN_cdi_plos_journals_1310270247
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310270247
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0026454
