Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MS...
Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MSP Domain as Revealed by NMR and MD Simulations
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS). Here using CD, NMR and molecular dynamics (MD) simulations, we characterized the structure, stability, dynamics and binding capacity of the T46I-MSP domain. The results reveal: 1) unli...
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Full title
Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MSP Domain as Revealed by NMR and MD Simulations
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TN_cdi_plos_journals_1310648849
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310648849
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0027072
