A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism...
A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8. The region contains LHX3, which codes for a transcription factor essential for pituitary development. Dwarfs have a de...
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Full title
A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs
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TN_cdi_plos_journals_1310733913
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310733913
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0027940
