Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform
Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induced obesity. Hence, DGAT1 is considered a potential therapeutic target for treating obesity and relat...
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Full title
Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform
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TN_cdi_plos_journals_1310775760
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1310775760
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0027009
